CKMT1A anticorps (C-Term)

N° du produit ABIN5514690

Cet anticorps Lapin Polyclonal détecte spécifiquement CKMT1A dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CKMT1A anticorps (C-Term) (ABIN5514690)

Antigène: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CKMT1A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CKMT1A anticorps

Épitope: C-Term

Séquence: QKRGTGGVDT AATGGVFDIS NLDRLGKSEV ELVQLVIDGV NYLIDCERRL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CKMT1A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CKMT1A

Antigène: CKMT1A (Creatine Kinase, Mitochondrial 1A (CKMT1A))

Autre désignation: CKMT1A

Sujet: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Alias Symbols: CKMT1, U-MtCK, mia-CK

Protein Interaction Partner: UBC, MDM2, SUZ12, gag-pol, CUL3, ASB9, VDAC1, SLC25A5, CKMT1A,

Protein Size: 417

ID gène: 548596

NCBI Accession: NM_001015001, NP_001015001

UniProt: P12532