SUPT5H anticorps (N-Term)

N° du produit ABIN5514714

Cet anticorps Lapin Polyclonal détecte spécifiquement SUPT5H dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour SUPT5H anticorps (N-Term) (ABIN5514714)

Antigène: SUPT5H (Transcription Elongation Factor SPT5 (SUPT5H))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUPT5H est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SUPT5H anticorps

Épitope: N-Term

Séquence: SAAGSEKEEE PEDEEEEEEE EEYDEEEEEE DDDRPPKKPR HGGFILDEAD

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SUPT5H

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SUPT5H

Antigène: SUPT5H (Transcription Elongation Factor SPT5 (SUPT5H))

Autre désignation: SUPT5H

Sujet: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Alias Symbols: SPT5, SPT5H, Tat-CT1

Protein Size: 1087

ID gène: 6829

NCBI Accession: NM_001111020, NP_001104490

UniProt: O00267