APEX2 anticorps (C-Term)

N° du produit ABIN5515372

L’anticorps anti-APEX2 Polyclonal Lapin est utilisé pour la détection de APEX2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour APEX2 anticorps (C-Term) (ABIN5515372)

Antigène: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APEX2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-APEX2 anticorps

Épitope: C-Term

Séquence: LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE LRTSFWKSVL AGPLRTPLCG

Homologie: Cow: 85%, Horse: 93%, Human: 100%, Rat: 77%

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human APEX2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur APEX2

Antigène: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Autre désignation: APEX2

Sujet: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alias Symbols: APE2, XTH2, ZGRF2, APEXL2

Protein Interaction Partner: UBC, PDE12, APP, NEDD4L, CCDC85B, NINL, HOOK2, PGR, CALCOCO2, TRIM37, EFEMP2, TRAF2, PCNA,

Protein Size: 518

ID gène: 27301

NCBI Accession: NM_014481, NP_055296

UniProt: Q9UBZ4