SMC6 anticorps (N-Term)

N° du produit ABIN5516172

Cet anticorps Lapin Polyclonal détecte spécifiquement SMC6 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour SMC6 anticorps (N-Term) (ABIN5516172)

Antigène: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC6 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMC6 anticorps

Épitope: N-Term

Séquence: MAKRKEENFS SPKNAKRPRQ EELEDFDKDG DEDECKGTTL TAAEVGIIES

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SMC6

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SMC6

Antigène: SMC6 (SMC6 Structural Maintenance of Chromosomes 6-Like 1 (SMC6))

Autre désignation: SMC6

Sujet: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.

Alias Symbols: SMC-6, hSMC6, SMC6L1

Protein Size: 1091

ID gène: 79677

NCBI Accession: NM_001142286, NP_001135758

UniProt: Q96SB8