Urm1 anticorps (N-Term)

N° du produit ABIN5516189

Cet anticorps anti-Urm1 Polyclonal Lapin (ABIN5516189) détecte spécifiquement Urm1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Urm1 anticorps (N-Term) (ABIN5516189)

Antigène: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Urm1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Urm1 anticorps

Épitope: N-Term

Fonction: URM1 Antibody - N-terminal region

Séquence: TLPGQEEPWD IRNLLIWIKK NLLKERPELF IQGDSVRPGI LVLINDADWE

Attributs du produit: This is a rabbit polyclonal antibody against URM1. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human URM1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75809-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Urm1

Antigène: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Autre désignation: URM1

Sujet:

Background Information: URM1 acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). URM1 serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Alternative Symbols: C9orf74

Poids moléculaire: 11kDa

ID gène: 81605

NCBI Accession: NP_112176

UniProt: Q9BTM9