HMGCR anticorps (C-Term)

N° du produit ABIN5516965

L’anticorps anti-HMGCR Polyclonal Lapin est utilisé pour la détection de HMGCR dans des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin et Saccharomyces cerevisiae. Il a été validé pour WB.

Aperçu rapide pour HMGCR anticorps (C-Term) (ABIN5516965)

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Porc, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGCR est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HMGCR anticorps

Épitope: C-Term

Fonction: HMGCR Antibody - C-terminal region

Séquence: PSIEIGTVGG GTNLLPQQAC LQMLGVQGAC KDNPGENARQ LARIVCGTVM

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HMDH. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human HMGCR

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44343-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur HMGCR

Antigène: HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))

Autre désignation: HMGCR

Sujet:

Background Information: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase

Alternative Symbols: LDLCQ3

Protein Name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Poids moléculaire: 97kDa

ID gène: 3156

UniProt: P04035

Pathways: AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha