PDP anticorps (N-Term)

N° du produit ABIN5517423

Cet anticorps Lapin Polyclonal détecte spécifiquement PDP dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour PDP anticorps (N-Term) (ABIN5517423)

Antigène: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PDP anticorps

Épitope: N-Term

Séquence: SSSYIPQSRL RYTPHPAYAT FCRPKENWWQ YTQGRRYAST PQKFYLTPPQ

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PDP1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PDP

Antigène: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Autre désignation: PDP1

Sujet: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alias Symbols: PDH, PDP, PDPC, PPM2C

Protein Size: 537

ID gène: 54704

NCBI Accession: NM_001161779, NP_001155251

UniProt: Q9P0J1