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WDR48 anticorps (C-Term)

WDR48 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN5517644
  • Antigène Voir toutes WDR48 Anticorps
    WDR48 (WD Repeat Domain 48 (WDR48))
    Épitope
    • 10
    • 10
    • 7
    • 1
    C-Term
    Reactivité
    • 20
    • 4
    • 3
    Humain
    Hôte
    • 21
    Lapin
    Clonalité
    • 21
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp WDR48 est non-conjugé
    Application
    • 19
    • 17
    • 15
    • 13
    • 4
    • 1
    Western Blotting (WB)
    Séquence
    YEKIINLDNE SQTTSSSNNE KPGEQEKEED IAVLAEEKIE LLCQDQVLDP
    Purification
    Affinity purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human WDR48
    Top Product
    Discover our top product WDR48 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    WDR48 (WD Repeat Domain 48 (WDR48))
    Autre désignation
    WDR48 (WDR48 Produits)
    Synonymes
    anticorps P80, anticorps UAF1, anticorps 8430408H12Rik, anticorps mKIAA1449, anticorps WD repeat domain 48, anticorps WDR48, anticorps Wdr48
    Sujet
    Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself (PubMed:18082604). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

    Alias Symbols: P80, UAF1, SPG60

    Protein Size: 677
    ID gène
    57599
    NCBI Accession
    NM_001303402, NP_065890
    UniProt
    Q8TAF3
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