GABBR1 anticorps (AA 186-405)

N° du produit ABIN5518835

Cet anticorps anti-GABBR1 est un anticorps Lapin Polyclonal détectant GABBR1 dans WB. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour GABBR1 anticorps (AA 186-405) (ABIN5518835)

Antigène: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABBR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GABBR1 anticorps

Épitope: AA 186-405

Fonction: Anti-GABA B Receptor 1/GABBR1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-GABA B Receptor 1/GABBR1 Antibody Picoband® (ABIN5518835). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human GABBR1 recombinant protein (Position: Q186-D405). Human GABBR1 shares 99.5% amino acid (aa) sequence identity with both mouse and rat GABBR1.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
1. White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (December 2000). "The GABAB receptor interacts ly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967-72. 2. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (December 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature. 396 (6712): 679-82.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur GABBR1

Antigène: GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))

Autre désignation: GABBR1

Sujet:

Synonyms: Gamma-aminobutyric acid type B receptor subunit 1,GABA-B receptor 1,GABA-B-R1,GABA-BR1,GABABR1,Gb1,GABBR1,GPRC3A,

Tissue Specificity: Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. .

Background: Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene. This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA (B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined.

Poids moléculaire: 108 kDa

ID gène: 2550

Pathways: Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process