HPSE anticorps (AA 206-457)

N° du produit ABIN5518844

Détail du produit anti-HPSE anticorps

Antigène: HPSE (Heparanase (HPSE))

Épitope: AA 206-457

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HPSE est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Heparanase(Hpse) detection. Tested with WB in Mouse.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Heparanase(Hpse) detection. Tested with WB in Mouse.
Gene Name: heparanase
Protein Name: Heparanase

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Heparanase 1 recombinant protein (Position: K206-K457). Mouse Heparanase 1 shares 80.2% and 96.4% amino acid (aa) sequence identity with human and rat Heparanase 1, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-HPSE (ABIN5518844)

Qin, Xu, Qi, Guo, Wang, Xu, Qiao, Gu, Niu: "Evaluation of the C-domain of heparanase during AGE-induced macrophage inflammatory response." dans: Experimental and therapeutic medicine, Vol. 14, Issue 2, pp. 1017-1022, (2017) (PubMed).

Huining, Yi, Dihong, Yifeng, Man, Ting, Jingting: "Inhibition of choriocarcinoma by Fe3O4-dextran-anti-β-human chorionic gonadotropin nanoparticles containing antisense oligodeoxynucleotide of heparanase." dans: International journal of nanomedicine, Vol. 8, pp. 4371-8, (2014) (PubMed).

Détails sur HPSE

Antigène: HPSE (Heparanase (HPSE))

Autre désignation: Hpse (HPSE Produits)

Synonymes: anticorps im:7144134, anticorps hpa, anticorps hpa1, anticorps hpr1, anticorps hpse1, anticorps hse1, anticorps HPSE, anticorps HPA, anticorps HPA1, anticorps HPR1, anticorps HPSE1, anticorps HSE1, anticorps Hpa, anticorps Hpr1, anticorps Hep, anticorps heparanase, anticorps HPSE, anticorps hpse, anticorps Hpse

Sujet: Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis. The successful penetration of the endothelial cell layer that lines the interior surface of blood vessels is an important process in the formation of blood borne tumour metastases. Heparan sulfate proteoglycans are major constituents of this layer and it has been shown that increased metastatic potential corresponds with increased heparanase activity for a number of cell lines.

Synonyms: Heparanase | 3.2.1.166 | Endo-glucoronidase | Heparanase-1 | Hpa1 | Heparanase 8 kDa subunit | Heparanase 50 kDa subunit | HPSE | HEP | HPA | HPA1 | HPR1 | HPSE1 | HSE1 | Q6YGZ1

ID gène: 15442

Pathways: Glycosaminoglycan Metabolic Process