SUPT5H anticorps (AA 395-424)

N° du produit ABIN5531040

Détail du produit anti-SUPT5H anticorps

Antigène: SUPT5H (Transcription Elongation Factor SPT5 (SUPT5H))

Épitope: AA 395-424

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUPT5H est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SUPT5H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the Central region of human SUPT5H.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur SUPT5H

Antigène: SUPT5H (Transcription Elongation Factor SPT5 (SUPT5H))

Autre désignation: SUPT5H (SUPT5H Produits)

Synonymes: anticorps SPT5, anticorps SPT5H, anticorps Tat-CT1, anticorps F13P17.5, anticorps F13P17_5, anticorps Spt5, anticorps etID10129.15, anticorps etID37101.15, anticorps fb37g01, anticorps fb95e05, anticorps fog, anticorps foggy, anticorps wu:fb37g01, anticorps wu:fb95e05, anticorps wu:fc10f02, anticorps spt5, anticorps spt5h, anticorps tat-ct1, anticorps CG7626, anticorps DSIF, anticorps Dmel\\CG7626, anticorps Dspt5, anticorps dDSIF, anticorps dSpt5, anticorps CaO19.1453, anticorps SPT5 homolog, DSIF elongation factor subunit, anticorps transcription elongation factor SPT5, anticorps Transcription elongation factor Spt5, anticorps transcription elongation factor Spt5, anticorps transcription elongation factor spt5, anticorps hypothetical protein, anticorps SPT5 homolog, DSIF elongation factor subunit S homeolog, anticorps CG7626 gene product from transcript CG7626-RA, anticorps Transcription elongation factor SPT5, anticorps transcription elongation factor, anticorps SUPT5H, anticorps LOC413814, anticorps AT2G34210, anticorps spt5, anticorps MGYG_08422, anticorps TERG_05483, anticorps PGTG_18458, anticorps supt5h, anticorps Supt5h, anticorps supt5h.S, anticorps Spt5, anticorps spt-5, anticorps SPT5

Sujet: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

Poids moléculaire: 121 kDa

ID gène: 6829

UniProt: O00267