PD-1 anticorps

N° du produit ABIN5540157

L’anticorps anti-PD-1 Monoclonal Souris est utilisé pour la détection de PD-1 dans des échantillons de Humain. Il a été validé pour WB et EIA.

Aperçu rapide pour PD-1 anticorps (ABIN5540157)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 1C4

Détail du produit anti-PD-1 anticorps

Specificité: Reactive with recombinant Human Programmed Cell Death-1 (PD-1). Reactivity with natural PD-1 has not been evaluated.

Purification: Affinity Chromatography on Protein G

Immunogène: 40kDa recombinant Human Programmed Cell Death-1 (PD-1).

Isotype: IgG1

Information d'application

Indications d'application: Indirect ELISA. Western Blot.

Restrictions: For Research Use only

Stockage

Buffer: 0.01M PBS, pH 7.2 without preservatives

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: cd279,pd1

Sujet: Programmed Cell Death-1 (PD-1), also called CD279, is a 288 amino acid cell surface protein that belongs to the immunoglobulin superfamily. The protein is expressed on T cells, B cells and macrophages. When PD-1 is joined with its ligand (CD274 or B7-H1), the immune cell's activation and effector function are attenuated. Research suggested that PD1 pathway is mainly involved with attenuation at periphery sites while the B7/CTLA-4 pathway is primarily involved with the attenuation of the activation of immune cells in secondary lymphoid organs. PD-1 pathway is implicated with cancer's immune-evasion, autoimmunity, and Listeria monocytogenes infection.

UniProt: Q15116

Pathways: Cancer Immune Checkpoints