FPR2 anticorps (2nd Extracellular Loop)

N° du produit ABIN5540339

Cet anticorps Lapin Polyclonal détecte spécifiquement FPR2 dans WB, FACS, IF et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour FPR2 anticorps (2nd Extracellular Loop) (ABIN5540339)

Antigène: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FPR2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-FPR2 anticorps

Épitope: 2nd Extracellular Loop

Séquence: ASWGGTPEER LKC

Specificité: This antibody recognizes a 38 kDa Human FPRL-1.

Purification: Affinity Chromatography on Protein G

Immunogène: A short peptide corresponding to the amino acids on the 2nd extracellular loop of Human FPRL1

Information d'application

Indications d'application: Western blot: 1/4000-1/5000. Immunofluorescence: 1/400-1/500. Flow Cytometry: 1/100 using HL-60 as positive control .

Restrictions: For Research Use only

Stockage

Buffer: 0.01M PBS, pH 7.2

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur FPR2

Antigène: FPR2 (Formyl Peptide Receptor 2 (FPR2))

Autre désignation: fpr2,fprl1

Sujet: Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer's disease.