ING2 anticorps (AA 1-280)

N° du produit ABIN5540825

Cet anticorps Souris Monoclonal détecte spécifiquement ING2 dans WB et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour ING2 anticorps (AA 1-280) (ABIN5540825)

Antigène: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ING2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT39E5

Détail du produit anti-ING2 anticorps

Épitope: AA 1-280

Purification: Protein-A affinity chromatography

Immunogène: Recombinant human ING2 (1-280aa) purified from E. coli

Information d'application

Indications d'application: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur ING2

Antigène: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Autre désignation: ing2,ing1l

Sujet: ING2 is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. This protein seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Also, It is component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides.

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling