SNAP25 anticorps (pSer187)

N° du produit ABIN5541045

L’anticorps Lapin Polyclonal anti-SNAP25 a été validé pour WB. Il convient pour détecter SNAP25 dans des échantillons de Humain, Rat, Souris, Poisson zèbre (Danio rerio), Cobaye et Primate.

Aperçu rapide pour SNAP25 anticorps (pSer187) (ABIN5541045)

Antigène: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Reactivité: Humain, Rat, Souris, Poisson zèbre (Danio rerio), Cobaye, Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNAP25 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SNAP25 anticorps

Épitope: pSer187

Specificité: Specific for the ~25k SNAP25 protein phosphorylated at Ser 187 in Western blots. Immunolabeling is completely blocked by blocked λ -Ptase.

Purification: Affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser187 of SNAP25

Isotype: Ig Fraction

Information d'application

Indications d'application: Western blot: 1/1000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg BSA per ml and 50 % glycerol

Stock: -20 °C

Stockage commentaire: Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur SNAP25

Antigène: SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))

Autre désignation: snap25

Sujet: SNAP25 (Synaptosomal associated pr otein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer's Disease (Greber et al., 1999). In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001). Increasing evidence suggests that SNAP-25 also modulates various ion channels, including voltage gated calcium channels (VGCCs) (Pozzi el al., 2008). Activation of PKC results in the phosphorylation of SNAP-25 on ser187 (Shu et al ., 2008). Phosphorylation of SNAP25 on ser187 is believed to cause inhibition of VGCC (Pozzi el al., 2008). Since ser187 phosphorylation is transiently induced by neuronal activity, SNAP25 creates a negative feedback mechanism for controlling neuronal excitability (Pozzi el al., 2008).

UniProt: P60881

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport