CMKLR1 anticorps

N° du produit ABIN5541107

Cet anticorps Souris Monoclonal détecte spécifiquement CMKLR1 dans IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour CMKLR1 anticorps (ABIN5541107)

Antigène: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CMKLR1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1A7

Détail du produit anti-CMKLR1 anticorps

Specificité: This antbody detects Chemerin receptor.

Purification: Affinity Chromatography on Protein G

Immunogène: DNA vaccine

Isotype: IgG2b

Information d'application

Indications d'application: Immunohistochemistry on paraffin sections: 1 μg/mL (1/200) predigestion w ith proteinase K required.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline pH 7.2 (PBS) Preservatives: 0.1 % Kathon Stabilizers: 5 mg/mL bovine serum albumin

Stock: 4 °C,-20 °C

Stockage commentaire: Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CMKLR1

Antigène: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Autre désignation: chemokine receptor-like 1

Sujet: G - protein coupled receptor ChemR23 is a 373 amino acid protein that belongs to the G - protein coupled receptor 1 family, with two potential glycosylation sites and one disulfide bond. The ligand Chemerin (or retinoic acid receptor responder protein 2 , RARRES2) is a 14 kDa protein found to stimulate chemotaxis of dendritic cells , monocytes / macrophages and natural killer cells to the site of inflammation. Accordingly, there is abundant expression of the receptor on these cells. ChemR23 is prominently expressed in developing osseous and cartilaginous tissue, as well as in tissues associated with hematopoietic and immune function including spleen, thymus, appendix, lymph node, bone marrow and fetal liver. The rece ptor is also found in adult parathyroid glands, in the cardiovascular system, brain, kidney, gastrointestinal and myeloid tissues and on endothelial cells. ChemR23 a cts as a cor eceptor for several SIV strains, as well as a primary HIV - 1 strain.

UniProt: Q99788