CEACAM7 anticorps

N° du produit ABIN5541193

Cité dans 6 publications. Cet anticorps anti-CEACAM7 Monoclonal Souris (Clone BAC2) (ABIN5541193) détecte spécifiquement CEACAM7 dans ICC, IF, FACS, IHC (fro) et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CEACAM7 anticorps (ABIN5541193)

Antigène: CEACAM7 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CEACAM7 est non-conjugé

Application: Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: BAC2

Détail du produit anti-CEACAM7 anticorps

Specificité: This antibody recognizes CEACAM7.

Purification: Affinity Chromatography on Protein G

Immunogène: CEACAM7/Fc fusion protein

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200. Flow cytometry: 1.2 μg/10 6 cells.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Phosphate buffered saline, pH 7.2 without preservatives

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-CEACAM7 (ABIN5541193)

Yue, Goldstein, Hollingsworth, Kaul, Brand, Haab: "The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays." dans: Molecular & cellular proteomics : MCP, Vol. 8, Issue 7, pp. 1697-707, (2009) (PubMed).

Bratke, Goettsching, Kuepper, Geyer, Luttmann, Virchow: "Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4 T cells by down-regulation of granzyme B." dans: Immunology, Vol. 127, Issue 3, pp. 338-44, (2009) (PubMed).

Thomas, Zhu, Schnaar, Alves, Konstantopoulos: "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow." dans: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15647-55, (2008) (PubMed).

Kilic, Oliveira-Ferrer, Neshat-Vahid, Irmak, Obst-Pernberg, Wurmbach, Loges, Kilic, Weil, Lauke, Tilki, Singer, Ergün: "Lymphatic reprogramming of microvascular endothelial cells by CEA-related cell adhesion molecule-1 via interaction with VEGFR-3 and Prox1." dans: Blood, Vol. 110, Issue 13, pp. 4223-33, (2007) (PubMed).

Fahlgren, Baranov, Frängsmyr, Zoubir, Hammarström, Hammarström: "Interferon-gamma tempers the expression of carcinoembryonic antigen family molecules in human colon cells: a possible role in innate mucosal defence." dans: Scandinavian journal of immunology, Vol. 58, Issue 6, pp. 628-41, (2003) (PubMed).

Schölzel, Zimmermann, Schwarzkopf, Grunert, Rogaczewski, Thompson: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." dans: The American journal of pathology, Vol. 156, Issue 2, pp. 595-605, (2000) (PubMed).

Détails sur CEACAM7

Antigène: CEACAM7 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 (CEACAM7))

Autre désignation: ceacam7

Sujet: CEA-related cell adhesion molecule 7 (CEACAM7, CGM2) belongs to the carcinoembryonic antigen (CEA) family (1). It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein which is only found on the apical surface of highly differentiated epithelial cells adult colon and on a small epithelial cell population in pancreatic ducts (2). CEACAM7 expression is completely lost upon malignant transformation already in hyperplastic polyps and early adenomas as well as in adenocarcinomas of the colon (2). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by one immunoglobulin constant-like A domain.

UniProt: Q14002