EGFL7 anticorps (C-Term)

N° du produit ABIN5541243

L’anticorps anti-EGFL7 Polyclonal Lapin est utilisé pour la détection de EGFL7 dans des échantillons de Humain. Il a été validé pour WB, IP, ICC, IF et IHC (fro).

Aperçu rapide pour EGFL7 anticorps (C-Term) (ABIN5541243)

Antigène: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGFL7 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-EGFL7 anticorps

Épitope: AA 178-273, C-Term

Specificité: This antibody recognizes VE-Statin / EGFL7 at C-term.

Purification: Protein A chromatography

Immunogène: Highly pure recombinant human EGFL7 (Pro178-Ser273) C-terminus derived from insect cells

Isotype: IgG

Information d'application

Indications d'application: Western blot: 2-5 μg/mL. Immunohistochemistry on Frozen sections. Immnunocytochemistry. Immunoprecipitation.

Restrictions: For Research Use only

Stockage

Buffer: PBS

Stock: 4 °C,-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur EGFL7

Antigène: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Autre désignation: egfl7

Sujet: EGFL7 (EGF-like domain-containing protein 7) regulates vascular tubulogenesis in vivo. During sprouting angiogenesis, groups of endothelial cells (ECs) migrate together in units called sprouts. EGFL7 regulates the proper spatial organization of ECs within each sprout and influences their collective movement. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro. EGFL7 (VE-Statin) is an ~ 30 kDa secreted protein that contains an Emilin-like (EMI) domain (a multimerization motif), and two epidermal growth factor (EGF) domains, one of which binds calcium. Based on these domains, it has been hypothesized that EGFL7 may self-assemble like extracellular matrix (ECM) proteins and, thus, could incorporate into ECM. EGFL7 has been reported to stimulate cell adhesion as well as motility in a manner similar to ECM proteins. EGFL7 has been shown to be primarily expressed by developing ECs but also by primordial germ cells and some central nervous system neurons. Interestingly, EGFL7 expression markedly decreases in ECs in postnatal life, but can be strongly up-regulated after various tissue injuries that lead to increased angiogenic responses.

UniProt: Q9UHF1