TIMD4 anticorps (AA 1-288)

N° du produit ABIN5541407

Cet anticorps Rat Monoclonal détecte spécifiquement TIMD4 dans FACS, IF, IHC (p) et ICC. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour TIMD4 anticorps (AA 1-288) (ABIN5541407)

Antigène: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMD4 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: RMT4-54

Détail du produit anti-TIMD4 anticorps

Épitope: AA 1-288

Specificité: Clone RMT4-54 specifically recognises mouse Tim-4. Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1 + cells), but not PEMs (peritoneal exudate Mac1 cells) [Nakayama, 2009]. Species: Mouse.

Purification: Affinity chromatography on Protein G

Immunogène: Mouse TIMD4 (amino acids 1-288), coupled with the Fc portion of mouse IgG2a

Isotype: IgG2a

Information d'application

Indications d'application: Flow cytometry: 1/25-1/200, use 10 μL of this suggested working dilution to label 10e6 cells in 100 μL. Immunofluorescence. Immunohistochemistry on Paraffin sections. Positive control: Mouse spleen. For functional assays Cat.-No. AM60019LE-N is recommended.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.09 % Sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur TIMD4

Antigène: TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))

Autre désignation: timd4

Sujet: TIMD4 / TIM-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of TIM-1, involved in T-cell expansion and cytokine production. TIMD4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between TIM-1 on Th2 cells and TIM-4 on DCs, enhances Th2 cell function. The TIMD4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma.

UniProt: Q6U7R4

Pathways: Cancer Immune Checkpoints