GZMK anticorps

N° du produit ABIN5541917

Cet anticorps Souris Monoclonal détecte spécifiquement GZMK dans FACS et EIA. Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour GZMK anticorps (ABIN5541917)

Antigène: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GZMK est non-conjugé

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: GM24C3

Détail du produit anti-GZMK anticorps

Specificité: This antibody recognizes Granzyme K (GZMK). Species: Human.

Purification: Affinity Chromatography on Protein G

Immunogène: GM24C3 was generated by genetic immunisation of BALB/c mice with an immunisation vector containing the Granzyme K cDNA

Isotype: IgG2b

Information d'application

Indications d'application: Flow Cytometry: 1.2 μg/10 6 cells. ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.2 without preservatives

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-GZMK (ABIN5541917)

Krause, Behrends, Borowski, Lohrmann, Lang, Myrtek, Lorenzen, Virchow, Luttmann, Friedrich: "Blockade of interleukin-13-mediated cell activation by a novel inhibitory antibody to human IL-13 receptor alpha1." dans: Molecular immunology, Vol. 43, Issue 11, pp. 1799-807, (2006) (PubMed).

Bratke, Kuepper, Bade, Virchow, Luttmann: "Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood." dans: European journal of immunology, Vol. 35, Issue 9, pp. 2608-16, (2005) (PubMed).

Détails sur GZMK

Antigène: GZMK (Granzyme K (Granzyme 3, Tryptase II) (GZMK))

Autre désignation: granzyme k (gzmk)

Sujet: Granzyme K (GrK) belongs to a family of trypsin-like serine proteases localised in the cytotoxic granules of activated T cells and NK cells. It encodes a 28 kDa serine protease whose gene is located on chromosome 5q11-12 close to the granzyme A-encoding gene. Like granzyme A, it has a trypsin-like specifity cleaving at the basic residues arginine and lysine. Granzyme K triggers rapid cell death independently of caspase activation with single-stranded DNA nicks and is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

UniProt: P49863