CD46 anticorps

N° du produit ABIN5541989

Cet anticorps Rat Monoclonal détecte spécifiquement CD46 dans WB, FACS, IF, ICC et EIA. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour CD46 anticorps (ABIN5541989)

Antigène: CD46

Reactivité: Souris, Rat

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC), Enzyme Immunoassay (EIA)

Clone: MM10

Détail du produit anti-CD46 anticorps

Specificité: The monoclonal antibody MM10 recognizes membrane cofactor protein (MCP), also known as CD46.

Purification: Purified

Immunogène: Mouse CD46-human Fc fusion protein.

Isotype: IgG2a

Information d'application

Indications d'application: Immuno Assays (Detector) Positive Control: Rat CD46 or Mouse CD46 variant as coating on a micro titer plate. Western blot (Researcher data). Flow Cytometry (Researcher data) Immunefluorescence Immuno histochemistry on Frozen Sections The typical starting working dilution is 1/50.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Buffer System: PBS Preservatives: 0.02 % Sodium Azide Stabilizers: 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CD46

Antigène: CD46

Autre désignation: cd46,mcp

Sujet: MCP is a type I membrane glycoprotein that consists of four isoforms i.e. two C-isoforms (51-58 kDa) and two BC isoforms (59-68 kDa) which arise by alternative splicing of a single CD46 gene. Membrane cofactor protein is expressed on every cell and tissue, with the exception of erythrocytes. Membrane cofactor protein serves to down-regulate the activation of complement on host tissue. MCP is a cofactor for factor 1-mediated cleavage of C3b and C4b and this way serves to protect the host cell against autologous attack. MCP is a receptor for several pathogens including measles virus, group A Streptococcus pyogenes and pathogenic Neisseria.

UniProt: O88174

Pathways: Regulation of Actin Filament Polymerization