CD46 anticorps

N° du produit ABIN5541990

L’anticorps Souris Monoclonal anti-CD46 a été validé pour WB, IF, ICC, IHC (fro) et EIA. Il convient pour détecter CD46 dans des échantillons de Rat.

Aperçu rapide pour CD46 anticorps (ABIN5541990)

Antigène: CD46

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD46 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: MM-1

Détail du produit anti-CD46 anticorps

Specificité: The monoclonal antibody MM.1 recognizes CD46, also known as membrane cofactor protein.

Purification: Purified

Isotype: IgG1

Information d'application

Indications d'application: Western blot: Rat testis lysate, non-reducing conditions, band size 38 kDa (Ref.1,4). Immuno Assays (Ref.1). Immunofluorescence (Ref.2-4). Immunohistochemistry on Frozen Sections (Ref.1-3). The typical starting working dilution is 1/50.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Buffer System: PBS Stabilizers: 0.1 % BSA

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CD46

Antigène: CD46

Autre désignation: cd46,mcp

Sujet: An immunohistological survey of rat tissues revealed that CD46 is expressed only in the testis and epididymis of adult rats more specifically, only by spermatozoa and late spermatozoal precursors. In contrast, in humans, CD46 is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to down-regulate the activation of complement on host tissue. It functions as a cofactor by binding to C3b and C4b. Binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. In human, it also serves as a receptor for measles virus. Two isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. The isoforms differ in the length. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR)).

UniProt: Q9Z0M4

Pathways: Regulation of Actin Filament Polymerization