Glycogen Synthase 1 anticorps (pSer641)

N° du produit ABIN5557475

Cet anticorps anti-Glycogen Synthase 1 est un anticorps Lapin Monoclonal détectant Glycogen Synthase 1 dans WB, IHC (p) et IF (cc). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour Glycogen Synthase 1 anticorps (pSer641) (ABIN5557475)

Antigène: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Glycogen Synthase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 10C1

Détail du produit anti-Glycogen Synthase 1 anticorps

Épitope: pSer641

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Synthetic peptide derived from human Glycogen synthase 1(S641), around 630-680aa (phospho S641).

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Glycogen Synthase 1

Antigène: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Autre désignation: Glycogen synthase 1

Sujet:

Synonyms: Glycogen synthase 1 phospho S640, Glycogen synthase 1 phospho Ser640, p-Glycogen synthase 1 S640, Glycogen synthase 1 muscle, Glycogen synthase 1, GSY, GYS, GYS1, EC 2.4.1.11, Glycogen synthase1, GYS 1, Starchsynthase muscle, UDP glucose glycogen glucosyltransferase, GYS1_HUMAN, Glycogen [starch] synthase, muscl.

Background: Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70 % identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation.

ID gène: 2997

UniProt: P13807

Pathways: Signalisation PI3K-Akt, AMPK Signaling, Cellular Glucan Metabolic Process