Recombinant Netrin 1 anticorps

N° du produit ABIN5564235

L’anticorps anti-Netrin 1 Monoclonal Human est utilisé pour la détection de Netrin 1 dans des échantillons de Humain et Souris. Il a été validé pour ELISA et Func.

Aperçu rapide pour Recombinant Netrin 1 anticorps (ABIN5564235)

Antigène: Netrin 1 (NTN1)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp Netrin 1 est non-conjugé

Application: ELISA, Functional Studies (Func)

Clone: 2F5

Détail du produit anti-Netrin 1 anticorps

Fonction: anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)

Specificité: Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

Aucune reactivité croisée: Souris

Réactivité croisée (Details): Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

Attributs du produit: Recombinant Antibody. Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles. Species cross-reactivity: Human, Mouse. Clone: 2F5. Isotype: Human IgG2lambda. Applications: ELISA, FUNC (Blocking). Host: HEK 293 cells. Liquid. In PBS containing 10 % glycerol. Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human Netrin-1.

Isotype: IgG2 lambda

Information d'application

Commentaires:

anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain.For negative control see Prod. No. AG-27B-0020PF.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur Netrin 1

Antigène: Netrin 1 (NTN1)

Autre désignation: Netrin-1

Sujet:

Alternate Names/Synonyms: NTN1, NP01-014

Product Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

UniProt: O95631

Pathways: Regulation of Cell Size