IL1F9 anticorps

N° du produit ABIN5564239

Détail du produit anti-IL1F9 anticorps

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL1F9 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Recognizes human IL-36gamma.

Réactivité croisée: Humain

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human IL-36gamma.

Clone: Jussy-1

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur IL1F9

Antigène: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Autre désignation: IL-36gamma (IL1F9 Produits)

Synonymes: anticorps IL-1F9, anticorps IL-1H1, anticorps IL-1RP2, anticorps IL1E, anticorps IL1F9, anticorps IL1H1, anticorps IL1RP2, anticorps Il36g, anticorps Il1f9, anticorps RGD1563019, anticorps IL36G, anticorps interleukin 36 gamma, anticorps interleukin 1 family, member 9, anticorps interleukin 36, gamma, anticorps interleukin-36 gamma, anticorps IL36G, anticorps Il1f9, anticorps Il36g, anticorps LOC100065031

Sujet: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines.