IL1F10 anticorps

N° du produit ABIN5564279

Détail du produit anti-IL1F10 anticorps

Antigène: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL1F10 est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: Recognizes human and mouse IL-38.

Réactivité croisée: Humain, Souris

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant human IL-38.

Clone: Nhat-1

Isotype: IgG2b

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur IL1F10

Antigène: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Autre désignation: IL-38 (IL1F10 Produits)

Synonymes: anticorps FIL1-theta, anticorps IL-1HY2, anticorps IL-38, anticorps IL1-theta, anticorps IL1HY2, anticorps interleukin 1 family, member 10, anticorps interleukin 1 family member 10, anticorps Il1f10, anticorps IL1F10

Sujet: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.