Huntingtin anticorps (pSer421)

N° du produit ABIN5596736

N° du produit (Fournisseur): 600-401-j79

Cet anticorps Lapin Polyclonal détecte spécifiquement Huntingtin dans IHC, WB et ELISA. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour Huntingtin anticorps (pSer421) (ABIN5596736)

Antigène: Huntingtin (HTT)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Huntingtin est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Détail du produit anti-Huntingtin anticorps

Épitope: pSer421

N° du produit (Fournisseur): 600-401-j79

Fournisseur: Rockland

Fonction: Huntington phospho S421 Antibody

Réactivité croisée (Details): A BLAST analysis was used to suggest cross-reactivity with human based on 100 % sequence homology.

Attributs du produit: Synonyms: rabbit anti-Huntington pS421 antibody, rabbit anti-Huntingtin pS421 antibody, HD protein, HTT, Huntington Disease Protein, Huntington disease, IT15, LOMARS

Purification: Anti-Huntingtin pS421 was affinity purified from monospecific antiserum by immunoaffinity chromatography and is directed against the phosphorylated form of the S421 residue.

Stérilité: Sterile filtered

Immunogène:

Immunogen: Anti-Huntington pS421 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region of human Huntington disease protein.

Immunogen Type: Conjugated Peptide

Isotype: IgG

Information d'application

Indications d'application:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-HTT antibody is useful for ELISA, Immunohistochemistry, and Western Blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately ~350 kDa corresponding to the appropriate cell lysate or extract.

Western Blot Dilution: 1 μg/mL

ELISA Dilution: 1: 10,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.07 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Preservative: None

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur Huntingtin

Antigène: Huntingtin (HTT)

Autre désignation: HTT

Sujet: Background: Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (HTT) protein. The disease is characterized by neurodegeneration and formation of neuronal intracellular inclusions primarily in the striatum and cortex, leading to personality changes, motor impairment, and dementia. The Huntington's disease protein is ~350kD in size and is localized in the brain. Anti-Huntington antibody is ideal for investigators interested in Neuroscience research.

ID gène: 3064

NCBI Accession: NP_002102

UniProt: P42858

Pathways: Signalisation PI3K-Akt, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport