DYRK1A anticorps (AA 674-763)

N° du produit ABIN560675

Détail du produit anti-DYRK1A anticorps

Antigène: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Épitope: AA 674-763

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DYRK1A est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Mouse monoclonal antibody raised against a partial recombinant DYRK1A.

Séquence: NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS ANTGPAHYMT EGHLTMRQGA DREESPMTGV CVQQSPVASS

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 7D10

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-DYRK1A (ABIN560675)

Rabaneda, Geribaldi-Doldán, Murillo-Carretero, Carrasco, Martínez-Salas, Verástegui, Castro: "Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation." dans: Biochimica et biophysica acta, Vol. 1863, Issue 12, pp. 3015-3026, (2016) (PubMed).

Souchet, Latour, Gu, Daubigney, Paul, Delabar, Janel: "Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise." dans: Journal of molecular neuroscience : MN, Vol. 55, Issue 2, pp. 318-23, (2015) (PubMed).

Thompson, Bhansali, Diebold, Cook, Stolzenburg, Casagrande, Besson, Leblond, Désiré, Malinge, Crispino: "DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3." dans: The Journal of experimental medicine, Vol. 212, Issue 6, pp. 953-70, (2015) (PubMed).

Najas, Arranz, Lochhead, Ashford, Oxley, Delabar, Cook, Barallobre, Arbonés: "DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome." dans: EBioMedicine, Vol. 2, Issue 2, pp. 120-34, (2015) (PubMed).

Blazek, Abeysekera, Li, Roper: "Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a." dans: Human molecular genetics, Vol. 24, Issue 20, pp. 5687-96, (2015) (PubMed).

Stringer, Abeysekera, Dria, Roper, Goodlett: "Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model." dans: Pharmacology, biochemistry, and behavior, Vol. 138, pp. 70-9, (2015) (PubMed).

Fant, Durieu, Chicanne, Payrastre, Sbrissa, Shisheva, Limanton, Carreaux, Bazureau, Meijer: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." dans: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, (2014) (PubMed).

Hibaoui, Grad, Letourneau, Sailani, Dahoun, Santoni, Gimelli, Guipponi, Pelte, Béna, Antonarakis, Feki: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." dans: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, (2014) (PubMed).

Rachdi, Kariyawasam, Guez, Aïello, Arbonés, Janel, Delabar, Polak, Scharfmann: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." dans: Diabetologia, Vol. 57, Issue 5, pp. 960-9, (2014) (PubMed).

García-Cerro, Martínez, Vidal, Corrales, Flórez, Vidal, Rueda, Arbonés, Martínez-Cué: "Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome." dans: PLoS ONE, Vol. 9, Issue 9, pp. e106572, (2014) (PubMed).

Thomazeau, Lassalle, Iafrati, Souchet, Guedj, Janel, Chavis, Delabar, Manzoni: "Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1138-47, (2014) (PubMed).

Janel, Sarazin, Corlier, Corne, de Souza, Hamelin, Aka, Lagarde, Blehaut, Hindié, Rain, Arbones, Dubois, Potier, Bottlaender, Delabar: "Plasma DYRK1A as a novel risk factor for Alzheimer's disease." dans: Translational psychiatry, Vol. 4, pp. e425, (2014) (PubMed).

Grau, Arató, Fernández-Fernández, Valderrama, Sindreu, Fillat, Ferrer, de la Luna, Altafaj: "DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors." dans: Frontiers in cellular neuroscience, Vol. 8, pp. 331, (2014) (PubMed).

Planque, Dairou, Noll, Bui, Ripoll, Guedj, Delabar, Janel: "Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain." dans: Journal of molecular neuroscience : MN, Vol. 50, Issue 1, pp. 1-6, (2013) (PubMed).

Abekhoukh, Planque, Ripoll, Urbaniak, Paul, Delabar, Janel: "Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice." dans: Molecular neurobiology, Vol. 47, Issue 1, pp. 105-16, (2013) (PubMed).

Altafaj, Martín, Ortiz-Abalia, Valderrama, Lao-Peregrín, Dierssen, Fillat: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." dans: Neurobiology of disease, Vol. 52, pp. 117-27, (2013) (PubMed).

Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." dans: PLoS ONE, Vol. 8, Issue 1, pp. e54285, (2013) (PubMed).

Tlili, Jacobs, de Koning, Mohamed, Bui, Dairou, Belin, Ducros, Dubois, Paul, Delabar, De Geest, Janel: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." dans: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, (2013) (PubMed).

Laguna, Barallobre, Marchena, Mateus, Ramírez, Martínez-Cue, Delabar, Castelo-Branco, de la Villa, Arbonés: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." dans: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, (2013) (PubMed).

Stefos, Soppa, Dierssen, Becker: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." dans: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).

Détails sur DYRK1A

Antigène: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Autre désignation: DYRK1A (DYRK1A Produits)

Synonymes: anticorps DYRK1A, anticorps dyrk, anticorps dyrk1, anticorps hp86, anticorps mnb, anticorps mnbh, anticorps DYRK, anticorps DYRK1, anticorps HP86, anticorps MNB, anticorps MNBH, anticorps MRD7, anticorps 2310043O08Rik, anticorps D16Ertd272e, anticorps D16Ertd493e, anticorps Dyrk, anticorps ENSMUSG00000074897, anticorps Gm10783, anticorps Mnbh, anticorps Mp86, anticorps mmb, anticorps PSK47, anticorps dual specificity tyrosine phosphorylation regulated kinase 1A, anticorps dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, anticorps dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a, anticorps dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog, anticorps DYRK1A, anticorps dyrk1a, anticorps Dyrk1a, anticorps dyrk1a.S

Sujet: Full Gene Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK,DYRK1,HP86,MNB,MNBH

ID gène: 1859

NCBI Accession: NM_001396

Pathways: Mitotic G1-G1/S Phases