BCR anticorps (AA 139-280)

N° du produit ABIN5611129

Cet anticorps anti-BCR est un anticorps Souris Monoclonal détectant BCR dans WB, ELISA et FACS. Adapté pour Humain.

Aperçu rapide pour BCR anticorps (AA 139-280) (ABIN5611129)

Antigène: BCR (Breakpoint Cluster Region (BCR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCR est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 1E11G12

Détail du produit anti-BCR anticorps

Épitope: AA 139-280

Fonction: BCR Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human BCR (AA: 139-280) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur BCR

Antigène: BCR (Breakpoint Cluster Region (BCR))

Autre désignation: BCR

Sujet: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 142.8 kDa

ID gène: 613

UniProt: P11274

Pathways: Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling