SIRPA anticorps (AA 235-373)

N° du produit ABIN5611267

Cet anticorps anti-SIRPA est un anticorps Souris Monoclonal détectant SIRPA dans FACS et ELISA. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour SIRPA anticorps (AA 235-373) (ABIN5611267)

Antigène: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIRPA est non-conjugé

Application: Flow Cytometry (FACS), ELISA

Clone: 2H7E2

Détail du produit anti-SIRPA anticorps

Épitope: AA 235-373

Fonction: CD172A Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD172A (AA: 235-373) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-SIRPA (ABIN5611267)

Deuse, Hu, Agbor-Enoh, Jang, Alawi, Saygi, Gravina, Tediashvili, Nguyen, Liu, Valantine, Lanier, Schrepfer: "The SIRPα-CD47 immune checkpoint in NK cells." dans: The Journal of experimental medicine, Vol. 218, Issue 3, (2021) (PubMed).

Détails sur SIRPA

Antigène: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Autre désignation: CD172A

Sujet: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Poids moléculaire: 55 kDa

UniProt: P78324