DC-SIGN/CD209 anticorps (AA 270-404)

N° du produit ABIN5611274

Cet anticorps Souris Monoclonal détecte spécifiquement DC-SIGN/CD209 dans WB, FACS et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour DC-SIGN/CD209 anticorps (AA 270-404) (ABIN5611274)

Antigène: DC-SIGN/CD209 (CD209) (CD209)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DC-SIGN/CD209 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Clone: 5C2A6

Détail du produit anti-DC-SIGN/CD209 anticorps

Épitope: AA 270-404

Fonction: CD209 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CD209 (AA: 270-404) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur DC-SIGN/CD209

Antigène: DC-SIGN/CD209 (CD209) (CD209)

Autre désignation: CD209

Sujet: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332, often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Poids moléculaire: 45.8 kDa

UniProt: Q9NNX6