PD-1 anticorps

N° du produit ABIN5633263

L’anticorps Souris Monoclonal anti-PD-1 a été validé pour FACS, Func et IHC (fro). Il convient pour détecter PD-1 dans des échantillons de Humain et Non-Human Primate.

Aperçu rapide pour PD-1 anticorps (ABIN5633263)

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-1 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: EH12-2H7

Détail du produit anti-PD-1 anticorps

Fonction: Anti-Hu CD279 Purified Low Endotoxin

Specificité: The mouse monoclonal antibody EH12.2H7 recognizes an extracellular epitope of CD279 / PD-1 (programmed cell death 1), a 55 kDa type I transmembrane protein expressed above all during T cell development, on activated T cells, activated B cells, and activated monocytes.

Réactivité croisée (Details): Human, Non-Human Primates

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

niveau d'endotoxine: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogène: recombinant human CD279

Isotype: IgG1 kappa

Information d'application

Indications d'application: Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Détails sur PD-1

Antigène: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Autre désignation: CD279

Sujet: Programmed cell death 1,CD279 / PD-1 (programmed cell death 1), a transmembrane protein of CD28/CTLA-4 family. It is expressed inducibly mainly on activated T, B, and myeloid cells and plays a role in maintaining peripheral self-tolerance. Binding to its ligands CD273 and CD274 is associated with inhibition of T cell proliferation and induction of their anergy. It is also expressed during thymic development. Some variants of CD279 are associated with susceptibility to systemic lupus erythematosus, type 1 diabetes, and rheumatoid arthritis.,PDCD1, PD1, SLEB2

ID gène: 5133

UniProt: Q15116

Pathways: Cancer Immune Checkpoints