TYMS anticorps (AA 60-174)

N° du produit ABIN5646953

Cet anticorps anti-TYMS Monoclonal Souris (Clone TYMS-1884) (ABIN5646953) détecte spécifiquement TYMS dans WB, IF, FACS et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour TYMS anticorps (AA 60-174) (ABIN5646953)

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TYMS est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: TYMS-1884

Détail du produit anti-TYMS anticorps

Épitope: AA 60-174

Fonction: TYMS Antibody / Thymidylate Synthase (azide and preservative free)

Attributs du produit: This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS, TYMS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Purification: Protein G affinity chromatography

Immunogène: A recombinant human parital protein corresponding to amino acids 60-174 was used as the immunogen for this TYMS antibody.

Isotype: IgG2c, kappa

Information d'application

Indications d'application: The optimal dilution of the TYMS antibody for each application should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the TYMS antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur TYMS

Antigène: TYMS (Thymidylate Synthetase (TYMS))

Autre désignation: TYMS

Sujet: This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS, TYMS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases