ALKBH7 anticorps (AA 1-221)

N° du produit ABIN5664063

Cet anticorps Lapin Polyclonal détecte spécifiquement ALKBH7 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour ALKBH7 anticorps (AA 1-221) (ABIN5664063)

Antigène: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ALKBH7 anticorps

Épitope: AA 1-221

Séquence: MAGTGLLALR TLPGPSWVRG SGPSVLSRLQ DAAVVRPGFL STAEEETLSR ELEPELRRRR YEYDHWDAAI HGFRETEKSR WSEASRAILQ RVQAAAFGPG QTLLSSVHVL DLEARGYIKP HVDSIKFCGA TIAGLSLLSP SVMRLVHTQE PGEWLELLLE PGSLYILRGS ARYDFSHEIL RDEESFFGER RIPRGRRISV ICRSLPEGMG PGESGQPPPA C

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human ALKBH7 (NP_115682.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:200 - 1:2000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur ALKBH7

Antigène: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Autre désignation: ALKBH7

Sujet: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro, but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity. Involved in fatty acid metabolism (By similarity.,ALKBH7,ABH7,SPATA11,UNQ6002,Epigenetics & Nuclear Signaling,DNA Damage & Repair,ALKBH7

Poids moléculaire: 24 kDa

ID gène: 84266

UniProt: Q9BT30