Recombinant TNF alpha (Humicade Biosimilar) anticorps

N° du produit ABIN5668144

Cet anticorps anti- est un anticorps Lapin Chimeric détectant dans ELISA. Adapté pour Humain.

Aperçu rapide pour Recombinant TNF alpha (Humicade Biosimilar) anticorps (ABIN5668144)

Antigène: TNF alpha (Humicade Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Inconjugué

Application: ELISA

Clone: CDP 571

Détail du produit

Fonction: Anti-TNF alpha [CDP 571 (Humicade)], Rabbit IgG, kappa

Specificité: The antibody binds to human TNF-alpha with a Kd of 0.087 nM.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: Human TNF-alpha

Isotype: IgG kappa

Information d'application

Indications d'application: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: TNF alpha (Humicade Biosimilar)

Classe de substances: Biosimilar

Sujet: TNFA, Tumour necrosis factor superfamily member 2, TNFSF2

UniProt: P01375