Recombinant TNF alpha (Humicade Biosimilar) anticorps

N° du produit ABIN5668144

Cet anticorps anti-TNF alpha (Humicade Biosimilar) Chimeric Lapin (Clone CDP 571) (ABIN5668144) détecte spécifiquement TNF alpha (Humicade Biosimilar) dans ELISA et Neut. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant TNF alpha (Humicade Biosimilar) anticorps (ABIN5668144)

Antigène: TNF alpha (Humicade Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Inconjugué

Application: ELISA, Neutralization (Neut)

Clone: CDP 571

Détail du produit

Fonction: Anti-TNF alpha [CDP 571 (Humicade)], Rabbit IgG, kappa

Specificité:

The antibody binds to human TNF-alpha with a Kd of 0.087 nM.

Application Notes original Clone: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.

Attributs du produit: NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: Human TNF-alpha

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Human

OriginalFormat: IgG4

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: TNF alpha (Humicade Biosimilar)

Classe de substances: Biosimilar

Sujet: TNFA, Tumour necrosis factor superfamily member 2, TNFSF2

UniProt: P01375