Recombinant TNF alpha (Adalimumab Biosimilar) anticorps

N° du produit ABIN5668145

Cet anticorps Human Monoclonal détecte spécifiquement TNF alpha (Adalimumab Biosimilar) dans ELISA, BR, IF et IHC. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Recombinant TNF alpha (Adalimumab Biosimilar) anticorps (ABIN5668145)

Antigène: TNF alpha (Adalimumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp TNF alpha (Adalimumab Biosimilar) est non-conjugé

Application: ELISA, Blocking Reagent (BR), Immunofluorescence (IF), Immunohistochemistry (IHC)

Clone: D2E7

Détail du produit anti-TNF alpha (Adalimumab Biosimilar) anticorps

Fonction: Anti-TNF alpha [D2E7 (Adalimumab)], Human IgG1, kappa

Specificité: Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta).

Réactivité croisée: Souris

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).

Isotype: IgG1 kappa

Information d'application

Indications d'application: Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Références pour anticorps anti-TNF alpha (Adalimumab Biosimilar) (ABIN5668145)

Gupta, Flaskamp, Roentgen, Juergens, Armero-Gimenez, Albrecht, Hemmerich, Arfi, Neuser, Spiegel, Schillberg, Yeliseev, Song, Qiu, Williams, Finnern: "Scaling eukaryotic cell-free protein synthesis achieved with the versatile and high-yielding tobacco BY-2 cell lysate." dans: Biotechnology and bioengineering, (2023) (PubMed).

Détails sur TNF alpha (Adalimumab Biosimilar)

Antigène: TNF alpha (Adalimumab Biosimilar)

Classe de substances: Biosimilar

Sujet: Tumor necrosis factor alpha

UniProt: P01375