Recombinant RSV (Felvizumab Biosimilar) anticorps

N° du produit ABIN5668207

Cet anticorps anti-RSV (Felvizumab Biosimilar) est un anticorps Lapin Chimeric détectant RSV (Felvizumab Biosimilar) dans ELISA et Func. Adapté pour Respiratory Syncytial Virus (RSV).

Aperçu rapide pour Recombinant RSV (Felvizumab Biosimilar) anticorps (ABIN5668207)

Antigène: RSV (Felvizumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Respiratory Syncytial Virus (RSV)

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp RSV (Felvizumab Biosimilar) est non-conjugé

Application: ELISA, Functional Studies (Func)

Clone: RSHZ19

Détail du produit anti-RSV (Felvizumab Biosimilar) anticorps

Fonction: Anti-RSV [RSHZ19 (Felvizumab)], Rabbit IgG, kappa

Specificité: This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.

Isotype: IgG kappa

Information d'application

Indications d'application: Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than felvizumab in neutralising RSV (Scott, 1999).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur RSV (Felvizumab Biosimilar)

Antigène: RSV (Felvizumab Biosimilar)

Classe de substances: Biosimilar

Sujet: SB 209763, respiratory syncytial virus