Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) anticorps

N° du produit ABIN5668226

Cet anticorps Human Monoclonal détecte spécifiquement ErbB2/Her2 (Trastuzumab Biosimilar) dans FACS, ELISA et IHC. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour Recombinant ErbB2/Her2 (Trastuzumab Biosimilar) anticorps (ABIN5668226)

Antigène: ErbB2/Her2 (Trastuzumab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp ErbB2/Her2 (Trastuzumab Biosimilar) est non-conjugé

Application: Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Clone: 4D5-8

Détail du produit anti-ErbB2/Her2 (Trastuzumab Biosimilar) anticorps

Fonction: Anti-erbB-2 (Her-2/neu) [4D5-8 (trastuzumab)], Human IgG1, kappa

Specificité: Oncogenic protein Her-2/neu (erbB-2), a member of the family of epidermal growth factor (EGF) receptors, overexpressed in 30 % of invasive breast cancers and 70 % of ductal carcinomata in situ, in a small percentage of melanomas, and in other malignancies originating from various organs, including ovary, kidney, colon, and bladder.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: A431 cells (human epidermoid carcinoma) (over)expressing EGFR.

Isotype: IgG1 kappa

Information d'application

Indications d'application: This antibody binds to erbB-2/Her-2/neu has therapeutic indications particularly in the treatment of breast cancer (c.f. Herceptin). It can also be used to detect HER-2 by flow cytometry or IHC (Glazyrin 2007).

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Références pour anticorps anti-ErbB2/Her2 (Trastuzumab Biosimilar) (ABIN5668226)

Maisel, Broka, Atwell, Bunch, Kupp, Singh, Mehta, Schroeder: "Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer." dans: Journal of translational medicine, Vol. 17, Issue 1, pp. 201, (2020) (PubMed).

Détails sur ErbB2/Her2 (Trastuzumab Biosimilar)

Antigène: ErbB2/Her2 (Trastuzumab Biosimilar)

Classe de substances: Biosimilar

Sujet: CD340, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, p185HER2, EGFR

UniProt: P04626