Recombinant ITGA5 (Volociximab Biosimilar) anticorps

N° du produit ABIN5668271

Cet anticorps Lapin Chimeric détecte spécifiquement dans BR, ELISA, FACS, IF et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant ITGA5 (Volociximab Biosimilar) anticorps (ABIN5668271)

Antigène: ITGA5 (Volociximab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Inconjugué

Application: Blocking Reagent (BR), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

Clone: M200

Détail du produit

Fonction: Anti-alpha 5 beta 1 Integrin [M200 (Volociximab)], Rabbit IgG, kappa

Specificité: The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM.

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Pureté: > 98 % as determined by SDS-PAGE

niveau d'endotoxine: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogène: Heterodimeric alpha5beta1Fc fusion protein

Isotype: IgG kappa

Information d'application

Indications d'application: The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.

Commentaires:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détail du antigène

Antigène: ITGA5 (Volociximab Biosimilar)

Classe de substances: Biosimilar

Sujet: Fibronectin receptor, CD49 antigen-like family member E, Integrin alpha-F, VLA-5, CD49e.

UniProt: P08648