CERS6 anticorps (AA 62-131)

N° du produit ABIN566979

Cet anticorps anti-CERS6 est un anticorps Souris Monoclonal détectant CERS6 dans WB, ELISA et IHC (p). Adapté pour Humain. Ce Primary Antibody a été cité dans 7+ publications.

Aperçu rapide pour CERS6 anticorps (AA 62-131) (ABIN566979)

Antigène: CERS6 (Ceramide Synthase 6 (CERS6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CERS6 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 5H7

Détail du produit anti-CERS6 anticorps

Épitope: AA 62-131

Fonction: Mouse monoclonal antibody raised against a partial recombinant LASS6.

Séquence: PCAIALNIQA NGPQIAPPNA ILEKVFTAIT KHPDEKRLEG LSKQLDWDVR SIQRWFRQRR NQEKPSTLTR

Réactivité croisée: Humain

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: LASS6 (NP_982288, 62 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-CERS6 (ABIN566979)

Suzuki, Cao, Kato, Komizu, Mizutani, Tanaka, Arima, Tai, Yanagisawa, Togawa, Shiraishi, Usami, Taniguchi, Fukui, Yokoi, Wakahara, Hasegawa, Mizutani, Igarashi, Inokuchi, Iwaki, Fujii, Satou et al.: "Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. ..." dans: The Journal of clinical investigation, Vol. 126, Issue 1, pp. 254-65, (2016) (PubMed).

Gerl, Bittl, Kirchner, Sachsenheimer, Brunner, Lüchtenborg, Özbalci, Wiedemann, Wegehingel, Nickel, Haberkant, Schultz, Krüger, Brügger: "Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions." dans: PLoS ONE, Vol. 11, Issue 4, pp. e0153009, (2016) (PubMed).

Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: "Bcl2L13 is a ceramide synthase inhibitor in glioblastoma." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 15, pp. 5682-7, (2014) (PubMed).

Laviad, Kelly, Merrill, Futerman: "Modulation of ceramide synthase activity via dimerization." dans: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 21025-33, (2012) (PubMed).

Yamane, Miyazawa, Moriya, Abe, Yamane et al.: "D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein ..." dans: Biochimie, Vol. 93, Issue 9, pp. 1446-59, (2011) (PubMed).

Mesicek, Lee, Feldman, Jiang, Skobeleva, Berdyshev, Haimovitz-Friedman, Fuks, Kolesnick: "Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells." dans: Cellular signalling, Vol. 22, Issue 9, pp. 1300-7, (2010) (PubMed).

dans: (PubMed).

Détails sur CERS6

Antigène: CERS6 (Ceramide Synthase 6 (CERS6))

Autre désignation: LASS6

Sujet: Full Gene Name: LAG1 homolog, ceramide synthase 6
Synonyms: CerS6,MGC129949,MGC129950

ID gène: 253782

NCBI Accession: NM_203463