MCU anticorps (C-Term)

N° du produit ABIN5673971

Cet anticorps anti-MCU est un anticorps Lapin Polyclonal détectant MCU dans WB. Adapté pour Souris.

Aperçu rapide pour MCU anticorps (C-Term) (ABIN5673971)

Antigène: MCU (Mitochondrial Calcium Uniporter (MCU))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCU est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MCU anticorps

Épitope: C-Term

Séquence: YPEARDRQYL LFFHKGAKKS RFDLEKYNQL KDAIAQAEMD LKRLRDPLQV

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of mouse CCDC109A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MCU

Antigène: MCU (Mitochondrial Calcium Uniporter (MCU))

Autre désignation: CCDC109A

Sujet: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity). Activity is regulated by MICU1 and MICU2 (By similarity). At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2, at higher Ca2+ levels MICU1 increases MCU activity (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (By similarity). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. Participates in mitochondrial permeability transition during ischemia-reperfusion injury (PubMed:26119731). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.

Alias Symbols: Gm64, AV064928, C10orf42, Ccdc109a, 2010012O16Rik, D130073L02Rik

Protein Size: 201

ID gène: 215999

NCBI Accession: NM_001033259, NP_001028431

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis