HIPK1 anticorps (AA 1-100) (Biotin)

N° du produit ABIN5675040

Cet anticorps Lapin Polyclonal détecte spécifiquement HIPK1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain, Souris, Singe et Macaque.

Aperçu rapide pour HIPK1 anticorps (AA 1-100) (Biotin) (ABIN5675040)

Antigène: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Reactivité: Humain, Souris, Singe, Macaque

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIPK1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-HIPK1 anticorps (Biotin)

Épitope: AA 1-100

Réactivité croisée: Humain, Macaque, Singe, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HIPK1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HIPK1

Antigène: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Autre désignation: HIPK1

Sujet:

Synonyms: Hipk 1, Hipk1, HIPK1_HUMAN, Homeodomain interacting protein kinase 1, Homeodomain interacting protein kinase 1 like protein, Homeodomain-interacting protein kinase 1, Myak, Nbak 2, Nbak2, Nuclear body associated kinase 2, Nuclear body associated kinase 2b

Background: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

ID gène: 204851

UniProt: Q86Z02