TCR alpha/beta anticorps (APC)

N° du produit ABIN567986

Il existe 5+ publications pour ce produit. L’anticorps anti-TCR alpha/beta Monoclonal Souris est utilisé pour la détection de TCR alpha/beta dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour TCR alpha/beta anticorps (APC) (ABIN567986)

Antigène: TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TCR alpha/beta est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: IP26

Détail du produit anti-TCR alpha/beta anticorps (APC)

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Size-Exclusion Chromatography and adjusted for direct use

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 15 mM Sodium Azide, 0.2 % (w/v) high-grade protease free BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE! This products is photosensitive and should be protected from light.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Références pour anticorps anti-TCR alpha/beta (APC) (ABIN567986)

Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: "NKp80 defines and stimulates a reactive subset of CD8 T cells." dans: Blood, Vol. 113, Issue 2, pp. 358-69, (2009) (PubMed).

Sullivan, Coscoy: "Downregulation of the T-cell receptor complex and impairment of T-cell activation by human herpesvirus 6 u24 protein." dans: Journal of virology, Vol. 82, Issue 2, pp. 602-8, (2008) (PubMed).

Chentouf, Ghannam, Bès, Troadec, Cérutti, Chardès et al.: "Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 1, pp. 409-20, (2007) (PubMed).

Ortonne, Huet, Gaudez, Marie-Cardine, Schiavon, Bagot, Musette, Bensussan: "Significance of circulating T-cell clones in Sezary syndrome." dans: Blood, Vol. 107, Issue 10, pp. 4030-8, (2006) (PubMed).

Edwards, Grzyb, Dressler, Mansel, Zava, Sledge, McGuire: "Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer." dans: Cancer research, Vol. 46, Issue 3, pp. 1306-17, (1986) (PubMed).

Détails sur TCR alpha/beta

Antigène: TCR alpha/beta (T Cell Receptor alpha/beta (TCR alpha/beta))

Autre désignation: T Cell Receptor / TCR alpha/beta

Sujet: The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.