CIRBP anticorps (C-Term)

N° du produit ABIN568702

Cet anticorps Chèvre Polyclonal détecte spécifiquement CIRBP dans WB, IHC (p) et EIA. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien et Boeuf (Vache).

Aperçu rapide pour CIRBP anticorps (C-Term) (ABIN568702)

Antigène: CIRBP (Cold Inducible RNA Binding Protein (CIRBP))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache)

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp CIRBP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-CIRBP anticorps

Épitope: C-Term

Séquence: C-RDSYDSYATH NE

Specificité: Recognizes CIRBP (aa 161-172).

Réactivité croisée (Details): Species reactivity (expected):Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human, Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide with sequence from the C-Terminus of the protein sequence according to NP_001271.1. Genename: CIRBP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CIRBP

Antigène: CIRBP (Cold Inducible RNA Binding Protein (CIRBP))

Autre désignation: CIRBP

Sujet: CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression. Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature.Synonyms: A18HNRNP, CIRP, Cold-inducible RNA-binding protein, Glycine-rich RNA-binding protein CIRP

ID gène: 1153

NCBI Accession: NP_001271

UniProt: Q14011

Pathways: Ribonucleoprotein Complex Subunit Organization