Ubiquitin hydrolase 1 anticorps

N° du produit ABIN5688748

L’anticorps anti-Ubiquitin hydrolase 1 Monoclonal Souris est utilisé pour la détection de Ubiquitin hydrolase 1 dans des échantillons de Humain, Boeuf (Vache), Souris et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour Ubiquitin hydrolase 1 anticorps (ABIN5688748)

Antigène: Ubiquitin hydrolase 1

Reactivité: Humain, Boeuf (Vache), Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: MCA-BH7

Détail du produit

Specificité: Specific for the ~24  kDa UCHL1 protein.

Purification: Total IgG fraction

Immunogène: Recombinant full length human UCHL1 purified from E. coli.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Stockage commentaire: Ubiquitin Hydrolase 1 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Détail du antigène

Antigène: Ubiquitin hydrolase 1

Sujet: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5. It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein. The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice. Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease. Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.

Poids moléculaire: 24 kDa

ID gène: 7345

UniProt: P09936