Connexin anticorps (C-Term)
L’anticorps Lapin Polyclonal anti-Connexin a été validé pour WB. Il convient pour détecter Connexin dans des échantillons de Poulet, Chien, Humain, Souris, Rat, Mouton, Xenopus laevis et Poisson zèbre (Danio rerio).
N° du produit ABIN5688865
Aperçu rapide pour Connexin anticorps (C-Term) (ABIN5688865)
Antigène
Connexin
Reactivité
Poulet, Chien, Humain, Souris, Rat, Mouton, Xenopus laevis, Poisson zèbre (Danio rerio)
Hôte
Lapin
Clonalité
Polyclonal
Application
Western Blotting (WB)
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Épitope
- C-Term
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Purification
- Affinity Purified
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Immunogène
- Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
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Indications d'application
- The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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Stock
- -20 °C
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Stockage commentaire
- Connexin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- Connexin
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Sujet
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
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Poids moléculaire
- 43 kDa
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ID gène
- 24392
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UniProt
- P08050
Antigène
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