GABRA1 anticorps (pSer327)

N° du produit ABIN5688897

Cet anticorps Lapin Polyclonal détecte spécifiquement GABRA1 dans WB. Il présente une réactivité envers Rat, Humain, Souris, Boeuf (Vache), Chien et Poulet.

Aperçu rapide pour GABRA1 anticorps (pSer327) (ABIN5688897)

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Reactivité: Rat, Humain, Souris, Boeuf (Vache), Chien, Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GABRA1 anticorps

Épitope: pSer327

Specificité: Specific for ~45k GABAA receptor γ2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by λ-phosphatase treatment.

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser327 of the GABAA receptor, y2 subunit.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: GABAA Receptor (Ser327) antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Détails sur GABRA1

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Autre désignation: GABAA Receptor

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gamma,s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKC? regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)

Poids moléculaire: 45 kDa

ID gène: 29709

UniProt: P18508