GABA B Receptor (pSer783) anticorps

N° du produit ABIN5688908

Détail du produit

Antigène: GABA B Receptor

Épitope: pSer783

Reactivité: Humain, Souris, Rat, Xenopus laevis, Poulet, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity Purified

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser783 of GABAB R2.

Information d'application

Indications d'application: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with mouse, human, non-human primate, chicken, bovine and Xenopus tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Stock: -20 °C

Stockage commentaire: GABAB Receptor antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Détail du antigène

Antigène: GABA B Receptor

Autre désignation: GABAB Receptor

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).

Poids moléculaire: 102 kDa

ID gène: 83633

UniProt: O88871