EWSR1 anticorps (AA 213-217)

N° du produit ABIN5689269

Cet anticorps Lapin Polyclonal détecte spécifiquement EWSR1 dans WB. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour EWSR1 anticorps (AA 213-217) (ABIN5689269)

Antigène: EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EWSR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EWSR1 anticorps

Épitope: AA 213-217

Specificité: This antibody detects endogenous levels of total EWS protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: EWS antibody was raised against a peptide sequence around aa.213~217 (T-Y-G-Q-P) derived from Human EWS.

Information d'application

Indications d'application: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store antibody at -20°C for up to one year.

Détails sur EWSR1

Antigène: EWSR1 (Ewing Sarcoma Breakpoint Region 1 (EWSR1))

Autre désignation: EWS

Sujet: This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11,22)(q24,q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Poids moléculaire: 85 kDa

ID gène: 2130

NCBI Accession: NP_053733

UniProt: Q9BZD1